U0126
Catalogue Number BIU1095
Synonym(s): 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene
- CAS Number
109511-58-2
- Commodity Code
2930909899
- MDL Number
MFCD01861186
- Purity
- 98%
- Notes
- Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. J. Biol. Chem. 273: 18623-18632 (1998).
- Formula Weight
- 380.49 g/mol
- Melting Point
- 172-173 °C
- Chemical Hazard
- Irritant
- GHS
-
- Hazard Statements
-
Causes skin irritation.|Causes serious eye irritation.|May cause respiratory irritation.
- Precautionary Statements
-
Use only outdoors or in a well-ventilated area.|Avoid breathing dust/fumes.|Wear protective gloves: hazard.Use only outdoors or in a well-ventilated area.|Avoid breathing dust/fumes.|Wear protective gloves
protective clothing: hazard. protective clothing
eye protection and face protection.|Wash all exposed external body areas thoroughly after handling.|IF IN EYES: Rinse cautiously with : hazard. eye protection and face protection.|Wash all exposed external body areas thoroughly after handling.|IF IN EYES: Rinse cautiously with
- MSDS
- Typical Batch COA
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