U0126

CAS: 109511-58-2 | BIU1095 | U0126

Catalogue Number BIU1095

Synonym(s): 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene

CAS Number

109511-58-2

Commodity Code

2930909899

MDL Number

MFCD01861186

Purity
98%
Notes
Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. J. Biol. Chem. 273: 18623-18632 (1998).

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