E-64

Product Description

E-64, also known as Epoxysuccinyl-L-leucylamido-(4-guanidino)butane (CAS: 66701-25-5), is a protease inhibitor , and its binding modes with papain, actinidin, cathepsin L, and cathepsin K have been reviewed at the atomic level. E-64 has been widely used as a potent and irreversible (covalent-type) inhibitor for many cysteine proteases such as papain, ficin, actinidin, cathepsin B and L. E-64 will not inhibit serine proteases (except trypsin), and it inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition; it is permeable in cells and tissues & has low toxicity.

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