Synonym(s): N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, AG 490, Tyrphostin B42

CAS Number

134036-52-5

Commodity Code

2926907090

MDL Number

MFCD00209833

Notes

Specific and potent JAK-2 protein tyrosine kinase inhibitor. Also inhibits EGF receptor autophosphorylation, with an IC50 of 100 nM. Inhibits DNA synthesis and cell growth; induces apoptosis. Biochem. Pharmacol. 40: 913-918 (1990).