Trimethylsilyl trifluoromethanesulphonate
Catalogue Number PC7867
Synonym(s):
Trimethylsilyl trifluoromethanesulphonate, also knows as Trimethylsilyl triflate or {[(Trifluoromethyl)sulphonyl]oxy}trimethylsilane, is an organosilicon.
In trifluoroacetic, it has been found to cleave, in the presence of thioanisole, a number of protecting groups currently employed in pep... Read More
- CAS Number
27607-77-8
- Commodity Code
2931900090
- MDL Number
MFCD00000406
- Purity
- 98%
- Formula Weight
- 222.26 g/mol
- Density
- 1.228 g/cm³
- Boiling Point
- 37-40/12mm °C
- Ref Index
- 1.36
- Flash Point
- 25 °C
- MSDS
- FTIR
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- Typical Batch COA
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Product Description
Trimethylsilyl trifluoromethanesulphonate, also knows as Trimethylsilyl triflate or {[(Trifluoromethyl)sulphonyl]oxy}trimethylsilane, is an organosilicon.
In trifluoroacetic, it has been found to cleave, in the presence of thioanisole, a number of protecting groups currently employed in peptide synthesis, without significant side reactions and with a much faster rate of reaction than trifluoromethanesulphonic acid in trifluoroacetic acid. This new deprotecting reagent has been used in solution and solid phase peptide syntheses of nueromedin U-25 (a 25-residue peptide) and a rabit stomach peptide (an 8-residue peptide), respectively.
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