S63845
Catalogue Number BISN0043
Synonym(s): α(R)-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-benzenepropanoic acid
- CAS Number
1799633-27-4
- Commodity Code
2934999090
- MDL Number
MFCD31382374
- Purity
- 98%
- Notes
- S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
- Formula Weight
- 829.26 g/mol
- Chemical Hazard
- Harmful/Irritant
- GHS
-
- Hazard Statements
-
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
- Precautionary Statements
-
P280: Wear {{{0|||message=<specify protection equipment>|||default=protective gloves/protective clothing/eye protection/face protection|||filter=(_)?P280_PROT_EQUIPMENT_.+}}}.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Re: hazard.P280: Wear {{{0|||message=<specify protection equipment>|||default=protective gloves/protective clothing/eye protection/face protection|||filter=(_)?P280_PROT_EQUIPMENT_.+}}}.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Re
- MSDS
- Typical Batch COA
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UK Stock
UK stock will be shipped internationally
US Stock
US stock is for US shipping only
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