S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statements
P280: Wear {{{0|||message=<specify protection equipment>|||default=protective gloves/protective clothing/eye protection/face protection|||filter=(_)?P280_PROT_EQUIPMENT_.+}}}.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Re: hazard.P280: Wear {{{0|||message=<specify protection equipment>|||default=protective gloves/protective clothing/eye protection/face protection|||filter=(_)?P280_PROT_EQUIPMENT_.+}}}.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Re
