Leupeptin hemisulphate

CAS: 103476-89-7 | BIMI2183 | Leupeptin hemisulphate

Catalogue Number BIMI2183

Synonym(s): Ac-Leu-Leu-argininal hemisulphate

Leupeptin hemisulphate is a protease inhibitor that is produced naturally by some species of the soil bacteria Streptomyces and thus inhibits the degradation of proteins. Unlike many synthetic protease inhibitors, it has very low toxicity to humans. It is a reversible inhibitor of serine and cyst... Read More

CAS Number

103476-89-7

Commodity Code

2925290090

MDL Number

MFCD00037012

Purity
>90%
Notes
Leupeptin is a peptide antibiotic, isolated from several Streptomyces species. It is a reversible inhibitor ofserine and cysteine proteases
Formula Weight
951.19 g/mol
Chemical Hazard
Irritant
GHS
Hazard Statements
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary Statements
P261: Avoid breathing {{{0|||message=<specify applicable conditions>|||default=dust/fume/gas/mist/vapours/spray|||filter=(_)?P261_INHAL_CONDITION_.+}}}. P271: Use only outdoors or in a well-ventilated area. P280: Wear {{{0|||message=<specify protection eq: hazard.P261: Avoid breathing {{{0|||message=<specify applicable conditions>|||default=dust/fume/gas/mist/vapours/spray|||filter=(_)?P261_INHAL_CONDITION_.+}}}. P271: Use only outdoors or in a well-ventilated area. P280: Wear {{{0|||message=<specify protection eq
MSDS
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Typical Batch COA
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Size
UK Stock
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Price
Quantity
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25mg
In Stock
Out of Stock
£70.00
50mg
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Out of Stock
£110.00
100mg
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Out of Stock
£205.00
Size 25mg
Price £70.00
UK Stock In Stock
US Stock Out of Stock
Size 50mg
Price £110.00
UK Stock In Stock
US Stock Out of Stock
Size 100mg
Price £205.00
UK Stock In Stock
US Stock Out of Stock

Product Description

Leupeptin hemisulphate is a protease inhibitor that is produced naturally by some species of the soil bacteria Streptomyces and thus inhibits the degradation of proteins. Unlike many synthetic protease inhibitors, it has very low toxicity to humans. It is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

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