4-(Pentafluorothio)benzaldehyde is a fluorinated organic building block that has been used in the preparation of agrochemical and pharmaceutical components. It has been used in the synthesis of fused heterocycles to treat liver infections caused by the Hepatitis B virus,[1] and aryl pyrollidines... Read More
4-(Pentafluorothio)benzaldehyde is a fluorinated organic building block that has been used in the preparation of agrochemical and pharmaceutical components. It has been used in the synthesis of fused heterocycles to treat liver infections caused by the Hepatitis B virus,[1] and aryl pyrollidines as a class of antimalarial agents.[2] Arylsulfur pentafluorides are common structural motifs in pesticides and the highly stable pentafluoro group is often considered as a 'super trifluoromethyl group' owing to its superior electronegativity and lipophilicity.
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1) https://worldwide.espacenet.com/patent/search/family/078957563/publication/WO2022116999A1?q=pn%3DWO2022116999
2) https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01972
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