3-(Difluoromethyl)benzyl bromide is a fluorinated organic building block that has been used in the synthesis of heterocyclic drug compounds as bromodomain inhibitors for the treatment of cancer.[1] Fluorinated motifs in drug compounds can impart an improvement in various medicinal chemistry param... Read More
3-(Difluoromethyl)benzyl bromide is a fluorinated organic building block that has been used in the synthesis of heterocyclic drug compounds as bromodomain inhibitors for the treatment of cancer.[1] Fluorinated motifs in drug compounds can impart an improvement in various medicinal chemistry parameters including bioavailability, metabolic stability and lipophilicity, which can lower costly drug attrition rates.
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1) https://www.nature.com/articles/s41416-020-01079-x
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